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Precision medicine

Winter et al. Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease, in review. bioRxiv

Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer spheroid models, Cell Reports (2021). Download PDF and Suppl. Info. See also MIT News.

Targeting minimal residual disease: a path to cure?, Nature Reviews Cancer (2018). Download PDF

Determining therapeutic susceptibility in multiple myeloma by single-cell mass accumulation, Nature Communications (2017). Download PDF and Suppl. Info. See also MIT News.

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate, Nature Biotechnology (2016). Download PDF and Suppl. Info. See also MIT News.

 

Device engineering

Measuring single-cell density with high throughput enables dynamic profiling of immune cell and drug response from patient samples, in revision, Nature Biomedical Engineering. bioRxiv

Noninvasive monitoring of single-cell mechanics by acoustic scattering, Nature Methods (2019). Download PDF and Suppl. Info. See also MIT News.

High-throughput single-cell growth measurements via serial microfluidic mass sensor arrays, Nature Biotechnology (2016). Download PDF and Suppl. Info. See also MIT News.

Weighing nanoparticles in solution at the attogram scale, PNAS (2014). Download PDF and Suppl. Info. See also MIT News.

Measuring single-cell density, PNAS (2011). Download PDF. Animation. See also MIT News.

Weighing of Biomolecules, Single Cells, and Single Nanoparticles in Fluid, Nature, 446 1066 (2007). Download PDF. See also News & Views.

 

Cell growth and metabolism

Single-cell monitoring of dry mass and dry density reveals exocytosis of cellular dry contents in mitosis, eLife (2022). Download PDF and Suppl. Info. See also MIT News.

Mammalian cell growth dynamics in mitosis, eLife (2019). Download PDF.

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes, Journal of Cell Biology (2016). Download PDF and Suppl. Info. See also JCB In Focus.

Direct observation of mammalian cell growth and size regulation, Nature Methods (2012). Download PDF. See also MIT News. Highlight in Nature Methods.

Cooperative nutrient accumulation sustains growth of mammalian cells, Scientific Reports (2015). Download PDF and Suppl. Info.

 

Process monitoring for biomanufacturing

The state of technological advancement to address challenges in the manufacture of rAAV gene therapies, Biotechnology Advances (2024). Download PDF

Weighing the DNA content of Adeno-Associated Virus vectors with zeptogram precision using nanomechanical resonators, Nano Letters (2022). Download PDF and Suppl. Info. See also Cell and Gene summary.

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies, Mol Ther Methods Clin Dev (2021). Download PDF

 

Cellular biophysics

Linking single-cell measurements of mass, growth rate and gene expression, Genome Biology (2018). Download PDF and Suppl. Info. See also MIT News.

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes, Journal of Cell Biology (2016). Download PDF and Suppl. Info. See also JCB In Focus.

Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells. PLoS ONE (2013). Download PDF. See also Suppl. Info.

Characterizing deformability and surface friction of cancer cells, PNAS (2013). Download PDF. See also MIT News.

 

Environmental microbiology

Direct quantification of sinking velocities across unicellular algae, Science Advances (2024). Download PDF

Single-cell mass distributions reveal simple rules for achieving steady-state growth, mBio (2023). Download PDF

Direct single-cell biomass estimates for marine bacteria via Archimedes’ principle, International Society for Microbial Ecology Journal (2017). Download PDF.

 

 

 

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